Fol. Biol. 2023, 69, 181-185

CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

Jaroslav A. Hubáček1,2, Tom Philipp3, Ondřej Májek4,5, Dana Dlouhá2, Věra Adámková6, Ladislav Dušek4,5

1Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
2Third Department of Medicine, Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University, Prague, Czech Republic
3Clinic of Rheumatology and Physiotherapy, Third Faculty of Medicine, Charles University and Thomayer University Hospital, Prague, Czech Republic
4Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
5Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic
6Preventive Cardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Received December 2023
Accepted January 2024

A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C→T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case-control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2-positive individuals (P = 0.48; OR; 95 % CI – 0.92; 0.73–1.16). No significant differences in the distribution of genotypes were found when considering co-dominant and recessive genetic models or various between-group comparisons. The CD14 polymorphism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.


This study was supported by the Ministry of Health of the Czech Republic – Conceptual Development of Research Organization (Institute for Clinical and Experimental Medicine – IKEM, IN 00023001).


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