Fol. Biol. 2023, 69, 75-80

https://doi.org/10.14712/fb2023069030075

Genetic Architecture of Pregnancy Loss: Co-inheritance of Risk Factors in Bosnian Women

Grażyna Adler1, Mateusz A. Adler2, Emir Mahmutbegović3

1Department of Studies in Antropogenetics and Biogerontology, Pomeranian Medical University, Szczecin, Poland
2Credit Suisse, sp. z o.o., Warsaw, Poland
3Institution of Health Protection of Women and Motherhood Canton Sarajevo, Sarajevo, Bosnia and Herzegovina

Received July 2023
Accepted October 2023

References

1. Adler, G., Garstka, A., Valjevac, A. et al. (2015) Prevalence of genetic prothrombotic risk factors: 1691G > A FV, 20210G > A PT and 677C > T MTHFR mutations in the Bosnian population. Ann. Hum. Biol. 42, 576-580. <https://doi.org/10.3109/03014460.2014.968618>
2. Adler, G., Mahmutbegovic, E., Uzar, I. et al. (2018a) First Bosnian study of the relationship between APOE rs7412 and rs429358 variants and pregnancy loss. Folia Biol. (Praha) 64, 65-69. <https://doi.org/10.14712/fb2018064020065>
3. Adler, G., Uzar, I., Mahmutbegovic, E. et al. (2018b) First Bosnian study of relationship between VDR rs731236 and rs1544410 variants and pregnancy loss. Balkan J. Clin. Lab. 26, 73.
4. Adler, G., Mahmutbegovic, E., Mahmutbegovic, N. et al. (2018c) Maternal HAMP rs104421768 variant is not linked to pregnancy loss in Bosnian women. Balkan J. Clin. Lab. 26, 72.
5. Adler, G., Mahmutbegovic, E., Uzar, I. et al. (2019) Relationship between H1 and H2 haplotypes of the 17q21 inversion and pregnancy loss in Bosnian population: a case-control study. G&A 3, 33-37.
6. Arias-Sosa, L. A., Acosta, I. D., Lucena-Quevedo, E. et al. (2018) Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss. J. Assist. Reprod. Genet. 35, 355-366. <https://doi.org/10.1007/s10815-017-1108-y>
7. Bigdeli, R., Younesi, M. R., Panahnejad, E. et al. (2018) Association between thrombophilia gene polymorphisms and recurrent pregnancy loss risk in the Iranian population. Syst. Biol. Reprod. Med. 64, 274-282. <https://doi.org/10.1080/19396368.2018.1456576>
8. Brenner, B., Sarig, G., Weiner, Z. et al. (1999) Thrombophilic polymorphisms are common in women with fetal loss without apparent cause. Thromb. Haemost. 1, 6-9.
9. Chatzidimitriou, M., Chatzidimitriou, D., Mavridou, M. et al. (2017) Thrombophilic gene polymorphisms and recurrent pregnancy loss in Greek women. Int. J. Lab. Hematol. 6, 590-595. <https://doi.org/10.1111/ijlh.12703>
10. Farahmand, K., Totonchi, M., Hashemi, M. et al. (2016) Thrombophilic genes alterations as risk factor for recurrent pregnancy loss. J. Matern. Fetal Neonatal Med. 8, 1269-1273. <https://doi.org/10.3109/14767058.2015.1044431>
11. Goodman, C. S., Coulam, C. B., Jeyendran, R. S. et al. (2006) Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss? Am. J. Reprod. Immunol. 4, 230-236. <https://doi.org/10.1111/j.1600-0897.2006.00419.x>
12. Hong, L. Y., Marren, A. (2018) Recurrent pregnancy loss: a summary of international evidence-based guidelines and practice. Aust. J. Gen. Pract. 47, 432-436.
13. Jusic, A., Balic, D., Avdic, A. et al. (2018) The association of factor V G1961A (factor V Leiden), prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Bosnian women. Med. Glas. (Zenica) 15, 158-163.
14. Mahmutbegovic, E., Marjanovic, D., Medjedovic, E. et al. (2017a) Prevalence of F5 1691G>A, F2 20210G>A, and MTHFR 677C>T polymorphisms in Bosnian women with pregnancy loss. Bosn. J. Basic Med. Sci. 17, 309-314.
15. Mahmutbegovic, E., Skonieczna-Żydecka, K., Valjevac, A. et al. (2017b) Lack of association between I/D ACE and -675 ID 4G / 5G PAI-1 polymorphisms and predicting risk of pregnancy loss (PROPALO) in Bosnian women. In: CMBEBIH 2017. Proceedings of the International Conference on Medical and Biological Engineering 2017, ed. Badnjevic, A., pp. 440-444, Springer, Singapore.
16. Mitic, G., Kovac, M., Povazan, L. et al. (2010) Inherited thrombophilia is associated with pregnancy losses that occur after 12th gestational week in Serbian population. Clin. Appl. Thromb. Hemost. 4, 435-439. <https://doi.org/10.1177/1076029609335518>
17. Liu, X., Chen, Y., Ye, C. et al. (2021) Hereditary thrombophilia and recurrent pregnancy loss: a systematic review and meta-analysis. Hum. Reprod. 36, 1213-1229. <https://doi.org/10.1093/humrep/deab010>
18. Padda, J., Khalid, K., Mohan, A. et al. (2021) Factor V Leiden G1691A and prothrombin gene G20210A mutations on pregnancy outcome. Cureus 8, e17185.
19. Peres Wingeyer, S., Aranda, F., Udry, S. et al. (2019) Inherited thrombophilia and pregnancy loss. Study of an Argentinian cohort. Med. Clin. (Barc.) 152, 249-254. <https://doi.org/10.1016/j.medcli.2017.12.019>
20. R Core Team (2021) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Retrieved from: https://www.R-project.org/
21. Sarig, G., Younis, J. S., Hoffman, R. et al. (2002) Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage. Fertil. Steril. 2, 342-347. <https://doi.org/10.1016/S0015-0282(01)02971-5>
22. Sotiriadis, A., Vartholomatos, G., Pavlou, M. et al. (2007) Combined thrombophilic mutations in women with unexplained recurrent miscarriage. Am. J. Reprod. Immunol. 2, 133-141. <https://doi.org/10.1111/j.1600-0897.2006.00454.x>
23. Vaiman, D. (2015) Genetic regulation of recurrent spontaneous abortion in humans. Biomed. J. 38, 11-24. <https://doi.org/10.4103/2319-4170.133777>
24. Wen, Y., He, H., Zhao, K. (2023) Thrombophilic gene polymorphisms and recurrent pregnancy loss: a systematic review and meta-analysis. J. Assist. Reprod. Genet. 40, 1533-1558. <https://doi.org/10.1007/s10815-023-02823-x>
25. Yan, Y., Fang, L., Li, Y. (2021) Association of MMP2 and MMP9 gene polymorphisms with the recurrent spontaneous abortion: a meta-analysis. Gene 767, 145173. <https://doi.org/10.1016/j.gene.2020.145173>
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